Spring 2017: Advanced Bioelectronics Systems (EEE 5279)

Class Type: In person or Online video
Schedule: MW 6:00 - 7:15 pm

Advanced Bioelectronics Systems is offered in Spring 2017. Although it is a graduate class, I encourage undergradaute students to enroll as well. The prerequisite of Electronics II is encouraged. Just email me if you have any questions (brian.kim@ucf.edu).

This will be a fun class for anyone who has interest in emerging biotechnologies and would like to learn the current role of Electrical Engineerings in this interesting field. In the Advanced Bioelectronics Systems course, a set of advanced bioelectronics and design techniques in electrical engineering used in recently biophysical and biomedical research will be highlighted.

This series of topics will include understanding the role of bioelectronics in emerging biotechnology, fundamental study of electrode-electrolyte interface, scalable fabrication techniques, design of low-noise amplifier (sub pico-ampere) and electronics, cellular and biomolecular measurement, implantable devices, and system design of bioelectronics. The class will finalize with practice designing bioelectronics for gene sequencing and biomedical diagnostics.

The list below includes the topics that will be covered:

1. Survey of advanced bioelectronics in emerging biotechnology
- General survey of emerging biotechnologies that takes advantage of expertise that grew from Electrical and Computer Engineering.

Image from Ion Torrent, Thermo Fisher Scientific

2. Massively parallel molecular and cellular system
- Survey of modern CMOS-based sensor systems for massively high-throughput to analyze molecular and cellular biology. Examples will be given from recent research from leading industries such as Ion Torrent (now Life Technologies) and Nanion.

Image from Nanion

3. Electrodes in electrolyte and its modeling (polarizable and nonpolarizable electrodes)
- In this topic, the electrochemical interface at the electrode-electrolyte will be discussed. The electron transfer at the polarizable or non-polarizable electrode in various application will be a crucial process to understand to design appropriate electronics for amplification and signal processing.

4. Fabrication techniques of bioelectronics
- In this topic, we will be covering the modern and classic CMOS fabrication methods as well as integration of basic sensors on electronics. The example includes JFET for pn junction low-leakage current, nMOS and pMOS above 180 nm size that are used for Analog Circuit Design.

5. Design of low-noise amplifiers and electronics
- Circuit design techniques to accomplish low-noise measurement tasks at high bandwidth in biotechnology will be discussed. Various of noise sources such as 1/f noise and high-frequency capacitive noise will be discussed as well as high-gain configurations.

6. Cellular and biomolecular measurement (Single-cell electrophysiology)
- System level understandings of single-cell electrophysiology will be provided. This includes the concept of electrophysiology, and electronics amplifier design, data sampling hardware design, and data processing and interpretation.

7. Implantable devices
- This topic will be covering implantable electronics such as retina implant and cochlear implant and the circuits that are used for close-loop feedback and data processing. It will also cover wireless communication, wireless power transfer, and closed-loop control circuitry for stimulation and detection.

Image from SNU Nano-Bioelectroncs & Systems Laboratory

8. System design of bioelectronics
- Special tasks involved in system-level design will be discussed. This topic will help students to understand, not only the front-end of detection, but also the overall electronics involved to create a useful and manufacturable product.

Image from UCF Bioelectronics lab

9. Gene sequencing: Nanopore detection of DNA translocation
- In this topic, we will be covering electronics and circuit design that is playing a key role in the gene sequencing measurements. I was a part of the gene sequencing industry and have some thoughts to share. The topic will cover subthreshold circuit design technique in CMOS to measure sub-nA current level as well as capacitive and resistive thermal noise analysis associated with nanopore detections.

Image from Oxford Nanopore Technologies

10. Biomedical Diagnostics: Pathogen and cancer
- This topic will review laboratory electronics and equipment as well as portable instrumentations that is facilitated for medical diagnostics. The examples will be controls, detection, and processing of real-time PCR thermocyclers.

Image from Cepheid Inc.